Rol de la función mitocondrial en el corazón y sus implicaciones en disfunciones cardíacas
Main Article Content
Keywords
Mitocondria, mitocondria, función cardíaca, falla cardiaca, falla cardíaca, disfunciones mitocondriales
Resumen
En este artículo de revisión, examinamos el papel de la mitocondria en el buen funcionamiento del corazón, y en la generación de diversas afecciones cardíacas, las cuales están caracterizadas por una baja producción
de energía por parte de las mitocondrias y, por ende, hay un aumento en la pérdida de cardiomiocitos que conlleva al mal funcionamiento del corazón. Se ha determinado, que ciertas disfunciones mitocondriales asociadas a trastornos cardíacos se relacionan con alteraciones del sistema de fosforilación oxidativa, así como, con la disminución de ciertos componentes estructurales como la cardiolipina y la formación de supercomplejos. Se estima que cerca del 2.3% de la población colombiana puede presentar una prevalencia a la falla cardíaca. La presente revisión tiene como objetivo dar a conocer los avances investigativos relacionados con enfermedades cardíacas ocasionadas por disfunción mitocondrial, así como, la identificación de diferentes investigaciones dirigidas en la creación de alternativas de tratamiento para dichas patologías, todo esto con el fin de contribuir a la construcción de líneas de trabajo que tomen a la mitocondria como blanco terapéutico.
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Publicado
nov 7, 2017
Article Details
Cómo citar
Cañas Arboleda, M., & Franco-Sierra, N. D. (2017). Rol de la función mitocondrial en el corazón y sus implicaciones en disfunciones cardíacas. Ingeniería Y Ciencia, 13(26), 233–268. https://doi.org/10.17230/ingciencia.13.26.9
Número
Sección
Artículos de revisión
Agencias de apoyo
Universidad EAFIT
Biografía del autor/a
Mariana Cañas Arboleda, Universidad EAFIT
Asistente de Investigación, Departamento de Ciencias Biológicas. Grupo de Investigación CIBIOP (Ciencias Biológicas y Bioprocesos)
Nicolás D Franco-Sierra, Universidad EAFIT.
Asistente de Investigación, Departamento de Ciencias Biológicas. Grupo de Investigación BEC (Biodiversidad, Evolución y Conservación)
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